TABLE OF CONTENTS
OBJECTIVES OF THIS STUDY
2.3.3 CAUSE OF
AND PATHOPHYSIOLOGICAL CHANGES
SPECIES IN MAN
5.2 PLASMODIUM OVALE
LIFE CYCLE 2.6.1
IN VERTEBRATE HOST
2.8 MALARIA IN
AND NEONATAL MALARIA
2.9 IMMUNITY IN
PROTEINS IN MALRIA
BIOCHEMISTRY OF CIRCULATING IMMUNE COMPLEX
2.12 CIRCULATING IMMUNE COMPLEXES IN
FOR TOTAL PROTEIN
3.3 .2 REAGENT
FOR CIRCULATING IMMUNE COMPLEXES
GLYCOL (PEG) 6000 SOLUTION
PATIENTS AND SUBJECTS
OF SERUM TOTAL PROTEIN
OF SERUM ALBUMIN BY BROMOCRESOL GREEN
3.8 ASSAY OF
CIRCULATING IMMUNE COMPLEXES (CICs)
Malaria is a febrile illness characterized by fever
and related symptoms (WHO, 1990).
is a disease caused by a blood borne protozoan parasite which is an
intracellular parasite belonging to the class Sporozoa and of the genus
Plasmodium and it is transmitted through the bite of an infected female
anopheles mosquito (CDC, 2002). There are four different parasites of this
genus which may give rise to malaria in man.
Malaria is probably one of the
oldest diseases known to mankind that has profound impact on our history.
History of malaria and its terrible effects is as ancient as the history of
civilization, therefore history of mankind itself (Ray et al., 1992). This ancient
disease is still the scourge of the tropic and subtropics Africa, the Middle
East, Asia and China and Central and South America are all endemic zones with
tens of Ilion cases annually (Lucas, 1992).
is one of the genus and cause the most ere and virulent form of the disease and
the only one to cause acute ality. In this study Plasmodium falciparum will be on focus since it is most prevalent
in Nigeria. This genus of malaria spend a part of their cycle in the red cell
of the host where the erythrocyticschizogony. They develop into merozoites and
undergo a cycle producing schizonts.
Each cycle terminates when the red cell rupture
releasing merozoites into the circulation to infect new red cells eliciting an
Malaria infection leads to the
formation of circulating immune complexes (Mibeiet al., 2005). The importance of circulating immune complexes (CIC)
and their relationship to various diseases has been the subject of
investigation for number of years. Formation of immune complexes is a
protective, on-going and usually benign process of a normally functioning
immune system. However, in some individual CIC are deposited in the walls of
blood vessels, especially in the glomerular capillaries where they cause tissue
biospecific binding between sites of the antibody and the determinant group of
the antigen result in the formation of antigen-antibody complex (AgAb) known as
immune complexes (McDougal and McDuffie, 1985). Since malaria has been known to
cause mortality this study is aimed at assessing the magnitude of circulating
immune Complexes and some biochemical parameters which include serum total
rein, albumin and globulin.
The science of immunology have suggested the use of
CIC to measure variety of clinically oriented condition, this current studies
,suggest that CIC determination can be important in the evaluation of in
disease and sometimes in monitoring the efficiency of therapy.
Studies have suggested that plasma protein pattern
is frequently abnormal in patients with acute malaria and disturbance in immune
responses makes the disease a major cause of morbidity and mortality in
patients with malaria.
There is therefore need to
determine CIC and serum proteins in patients suffering from malaria with a view
to understand the pathology of the infection.
OBJECTIVES OF THIS STUDY
This study is aimed at:
the serum protein levels and CIC level in cerebral malaria patients, those
currently on treatments, severe malaria and apparently healthy individuals.
the level among the different groups studied.
recommendations based on the results obtained and use of CIC in the diagnosis
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