ABSTRACT
Cola nitida has been in use in the eastern parts of Nigeria
for the management of certain ailments and as an aphrodisiac in the management
of some sexual dysfunctions. However the effects of this extract in some health
parameters in human objects have not been reported. This work, then, was aimed
at investigating the effect of water extracts of kola pods on lipoprotein
concentrations on albino wistar rats.
Rats were used in this study and they were divided into
several groups and fed with a high calorie food (cow’s brain) so as to increase
the blood lipoprotein concentration in the rat models. The effect of the water
extracts of the sample used was compared with a known drug and the results
statistically compared to ascertain the effect of the water extract on the rat
models.
The results of this work indicate that water extracts of
cola nitida pods can be used in the management of mild lipoprotein dysfunctions
thus substantiating the reasons for its use in sexual erectile functions.
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TABLE OF
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Title page
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Approval page -
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Dedication
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Acknowledgment -
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Abstract - -
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Table of contents - -
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CHAPTER ONE
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1.0 Introduction -
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CHAPTER TWO
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2.0
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Literature Review -
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2.1
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Kola
Nut Powered (Cola Nitida) -
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2.2
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Kola
pod components -
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2.3
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Geography
and distribution -
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2.4
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Lipoprotein
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2.5
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High
cholesterol diagnosis -
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2.6
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Low
cholesterol -
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2.7
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Changes during circulation -
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2.8
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Liver -
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CHAPTER THREE
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Materials and methods
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3.1
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Identification
and Extraction plant material -
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3.2
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Phytochemical Analysis -
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3.3
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Experimental Animal model -
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3.4
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Collection of Blood samples -
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3.5
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Lipid profile Analysis -
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CHAPTER FOUR
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Results
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Phytochemical composition of samples -
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CHAPTER FIVE
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Discussion
and conclusion
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5.1
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Discussion - -
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5.2
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Conclusion --
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Reference
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CHAPTER
ONE
1.1
INTRODUCTION
Cola
Nitida has been used in folk medicine as an aphrodisiac, an appetite suppressant, to treat morning sickness, migraine
headache, and indigestion (Esimone et al., 2007). It has also been
applied directly to the skin to treat wounds and inflammation (Newall et
al., 1996)on the teeth and gums. There has also been speculations
as to its use in the treatment of peptic ulcer, however, in Nigeria there is no
record of the incidence of peptic ulcer.
According to Esimone (2007),
cola nitida tree is native to West Africa. Cola nuts are obtained from cola
trees. Cola nitida belongs to the genus cola and family steriliaceae.
They are commonly used to counteract hunger and thirst; in some cases it is
used to control vomiting in pregnant woman and also as a principal stimulant to
keep awake and withstand fatigue by students, drivers, and other menial
workers.
Lipoproteins are found in the
liver and cells. The liver is the largest organ inside the body. The liver is
dark reddish-brown and consists of two
main lobes. There are over 300 billion specialized cells in the liver that are
connected by a well organized system of “bile”
ducts and blood vessels called the biliary system.
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