ABSTRACT
Infant mortality are among the health indicators of
importance in a given population or country.
it is the third sustainable development goal that by 2030, all the
united Nation member countries are expected to have reduced infant mortality
rate as low as 12 per 1000 live birth.
This study examined the determinants of infant mortality in Nigeria, the
study considered ten risk factors of infant mortality namely: Age of mother at
birth of the child, sex of the child, place of residence, mother’s level of
education, wealth index, parity, birth order, type of birth, size of the child
at birth, age of mother at first birth, Data were extracted from Nigeria
Demographic and Health Survey (NDHS) conducted in the year 2013 based on
national representative sample of 38,948 (urban
= 15,548 rural = 23,403) women
age 15-49 drawn from 38,522 (urban 15,859, rural 22,663) households selected
using a stratified two-stage cluster sampling technique. The study adopted four different models
namely: Standard Cox Hazard model Weibull Cox regression model,
Exponentiated-weibull regression model and Cox Frailty model. The study revealed that maternal age at birth
of the child, wealth index, mother’s level of education contribute
significantly to infant mortality in Nigeria.
The finding also showed that children born to mothers with no formal
education have a significantly higher risk of mortality than children born to
mothers who have primary, secondary or more than secondary education. Furthermore infant born to poorest households
measured by wealth index have higher risk of dying before reaching age
one.
TABLE OF CONTENTS
Cover Page i
Title Page ii
Declaration iii
Certification iv
Dedication v
Acknowledgement vi
Abstract vii
Table of Contents viii
List of Tables xi
CHAPTER 1: INTRODUCTION
1.1
Background to the Study 1
1.2
Statement of the Problem 5
1.3
Aims and Objective of the
Study 5
1.4
Significance of the Study 6
1.5
Scope of the Study 6
CHAPTER 2: REVIEW OF
LITERATURE
2.1
Reviews on Infant Mortality 7
2.2 Underlying
Factors of Infant Mortality Based on the Previous Studies 10
2.2.1 Educational attainment and
infant mortality 11
2.2.2 Wealth status and infant
mortality 13
2.2.3
Place of residence and infant mortality 14
2.2.4 Parental
occupation and infant mortality 15
2.2.5
Maternal age and infant mortality 15
2.2.6
Birth interval and infant mortality 16
2.2.7
Nutritional status and infant mortality 16
2.2.8
Environmental contamination and infant mortality 17
2.2.9 Health
seeking behaviour and infant mortality 18
2.2.10 Sex differentials 18
2.2.11 The size of a child at birth 19
2.3 Review
of Empirical Studies 19
CHAPTER 3: RESEARCH METHODOLOGY
3.1 Source of Data 24
3.2 Methods of Data Analysis 26
3.2.1 Weibull
distribution 26
3.2.2
Exponentiated weibull
distribution 27
3.3
Cox Proportional Hazard Model 28
3.4 Estimation of Parameters of the Cox
Proportional Hazard Model
based on the Different Timing Function
Distributions 29
3.5
Testing
the Significance of the Parameter Estimates of the Cox
Proportional
Hazard Model 30
3.6 Performance
Comparison Parameter among the Different Cox
Proportional
Hazard Models 30
3.7 Cox Frailty Model 30
3.8 Test for the Proportionality Assumption in Cox Proportional model
Using
Schoenfeild Residuals 32
CHAPTER
4: RESULTS AND DISCUSSION
4.1 Results 35
4.1.1 Fitting a standard cox-proportional hazard
model on the 2013
NDHS data 37
4.1.2 Testing the proportional hazard assumption using
the scaled
schoenfeld
residuals 39
4.1.3 Result of the fitted standard multiple cox
proportional hazard model
based on the ten
predictor variables 41
4.1.4 Result
of the fitted weibull cox proportional hazard model based
on the ten
predictor variables 43
4.1.5
Result of the Fitted exponentiated
weibull cox proportional hazard
model based on the ten predictor
variables 45
4.1.6
The results of fitting a shared frailty (location
of residence and
type of
birth effect model on 2013 Nigerian DHS data to determine
determinants
of infant mortality) 48
4.2 Discussion of the Results 51
CHAPTER 5: SUMMARY, CONCLUSIONS AND RECOMMENDATIONS
5.1 Summary
of the Findings 53
5.2 Conclusion 54
5.3 Recommendations 54
REFERENCES
APPENDICES
CHAPTER
1
INTRODUCTION
1.1 BACKGROUND TO THE STUDY
Death
remains an unpredictable event which means that it can happen at any time. Death is a phenomenon that is common to every
mankind regardless of tribe, nationality, status or any other factors. The
human society, having acknowledged this universal truth, has been continuously
trying to postpone and manage death since the dawn of civilization. The
developed nations of the world to some extent according to Islam-Uddin et al.,(2007) have been very successful
in their efforts towards reducing overall mortality in general and infant and
child mortality in particular but this is not the case in developing countries(Islam-Uddin,
et al.,2007).
Infant
mortality rates are important indicators of societal and national development as
they have been described as key markers of health equity and access. Ssewanyana
and Younger (2008) observed that reducing infant mortality is one of the
sustainable development goals and in fact it is the third sustainable development
goal (SDG3) which states that infant and child mortality rates are to be reduced
by two-thirds between 2015-2030. Kayode et al., (2012) described infant mortality
rate in sub-Saharan Africa as high and that of Southern Asia as moderate. The high
rate of infant mortality in sub- Saharan Africa has made it to generate much
research attention of health practitioners, scholars, the academia and other
relevant stakeholders in the health sector.
Infant mortality rate is undoubtedly a global population
and health indicator of policies, programmes and research significance. It is
one of the widely acknowledged demographic barometer for assessing a
population's overall health status, quality of living condition, level of
social and economic development and efficiency of a country's health system
(Mac Dorman and Mathews, 2009; Syamala, 2004). For instance, reducing infant
mortality rate is central to the achievement of Sustainable Development Goals (SDGs)-
specifically, the SDG 3 which focused on reducing mortality rate among children
under five. Hence, there has been a renewed commitment to complementing and
sustaining the MDG achievements during the post-2015 period. Moreover, IMR is a
vital component in the measurement of the Human Development Index (HDI)
(Mustafa and Odimegwu, 2008) which is a composite global indicator for
assessing and comparing countries' level of achievement in three critical
components of human development comprising measures of a long and healthy life,
knowledge and a decent living standard.
The loss of a child can be regarded as the loss of
innocent, most vulnerable, dependent and defenseless individual. The loss of a
child can be likened to a loss of hopes, dreams and loss of future. This is
because children are the future of a family. Therefore, the death of a child is
probably the most traumatic and devastating experience for a couple and a
nation, as this amounts to the death of their future. This fact makes the issue
of infant mortality very crucial. Infant mortality is one of the most sensitive
health indicators of the people. In fact it is one of the major measure of
child health and overall development of a nation. Infant mortality also helps
in examining the living standard, social and economic status of a country.
Reducing the prevalence of infant mortality is one of
the targets of Sustainable Development Goals (SDGs) of United Nations (UN) of
which Nigeria is signatory to. Hence, more efforts have been made to ensure
that this goal is actualized. Despite successes recorded so far, the prevalence
of infant mortality especially in developing country like Nigeria is still very
high as more than 16,000 infants die each day in the world (WHO, 2015).There
are several factors that could be responsible for the high incidence of infant
mortality. Researchers have made considerable efforts to indentify the
determinants factors driving the phenomenon. Antai (2010) indentified some
socio-economic and bio-demographic factors as major determinants of infant
mortality. These factors and classified them into two broad categories which
are endogenous and exogenous. Exogenous factors of infant mortality are factors
that have to do with the environment in which an infant is exposed and some of
which include exposure to infectious diseases, parasitic and respiratory
diseases. Such causes normally increase the risk of death in the post neonatal
period and they are easier to control. The endogenous causes of infant
mortality on the other hand are the biological factors which include congenital
malformation and circumstances of the delivery. These endogenous causes come to
manifestation in the neonatal period and oftentimes are difficult to control.
Jinadu et al., (1999)
posited that several of diseases causing child mortality have connections with
hygiene condition and unclean environment; these include feeding bottles,
utensils, inadequate disposal of house hold refuse, poor water storage, to
mention a few. Other researchers like Osonwa, et al., (2012) and Caldwell (2009) have also indentified some other
factors that can be associated with infant mortality. These include maternal
age at birth, sex of the child, type of marriage, maternal education and wealth
index. Caldwell, (2009) posited that children from poorer or rural households are
more vulnerable than their counterparts from richer or urban households. Also,
United Nations Children’s Fund (2010) posited that a child born to a
financially deprived and less educated family is at risk of death within the
first month of life. The reasons for these are obvious since the mother may be
poorly nourished during pregnancy, had little or no antenatal care and likely
to deliver in ill-equipped health facility.
Moreover, a lot of models have been applied to study
the determinant of infant mortality and one of the models that have gained
popularity in this regards is the Cox Regression Model developed by Cox in
1972. The Cox regression has been widely used in survival analysis. There are
various forms of Cox regression but the major difference is in the distribution
that the timing function is assumed to follow (Wegbom et al., 2016). Researchers like Wegbom et al., (2016) examined the determinants of child mortality in
Nigeria. The study made use of Weibull distribution because it has the ability
to model hazard function that are monotonically decreasing or increasing.
Weibull distribution is one of the most widely used distribution
in modeling infant mortality where the timing function is assumed to follow
Weibull distribution (Wegbom et al.,
2016). This distribution has become the
distribution of choice because of its suitability for hazard function that is
either monotonically decreasing or increasing (Wegbom et al., 2016). This is true because mortality in human population
is usually high in the first year of life, then it declines in other ages of
childhood and throughout most of the teenage years, then increasing slowly in adult ages to old ages. Although,
the Weibull distribution proposed by Weibull (1939) has been established to be
suitable in modeling mortality (Wegbom et
al., 2016), but over the years there have been an improvement on the
Weibull distribution which has led to the development of other forms of this
distribution.
There have been other forms of robust
Weibull distribution that have been proposed using Beta generator and the
method of transmutation (Eugene et al.,
2002; Shaw and Buckley, 2007).Prominent
among these improved Weibull distribution is the Beta-Weibull distribution by
Famoye et al., (2005), exponentiated Weibull by Gupta et al., (1998). These new classes of Weibull
distributions have been shown to give better representation and flexibility
than Weibull distribution. Therefore, the distribution that the timing function
is assumed to follow is very important in Cox regression model. Despite this
development, these recent forms of Weibull distribution have not been applied in
determining the determinant of mortality in Nigeria. Therefore, this study
intends to use the recent forms of Weibull distribution as the timing function
other than the convectional Weibull distribution.
1.2 STATEMENT OF PROBLEM
Infant mortality has been an international social
problem for a very long time. In a developing country like Nigeria, the
government has achieved remarkable decrease in infant mortality through the
implementation of health policies which improves infant health care and hence
increasing their survival rate. Yet, the prevalence is still high. Meeting the
Sustainable Development Goal (SDG) 3 of reducing infant mortality to as low as
12 per 1000 live births by 2030 remains a mirage as several studies reveal
shocking pictures of infant death.
Many researchers have identified that infant mortality
varies by demographic and socioeconomic factors (Antai 2010), A lot of models
have been applied to study the determinants of mortality and one of the models
that have gained popularity in this regard is the Cox proportional hazard model developed by Cox in 1972. The Cox
regression has been widely used in survival analysis (Amusa and Gatta, 2016,
Murithiand Murithi, 2015, Dahiru 2015, Maxwell et al., 2017, Nasejjeet.al.,
2015).There are various forms of Cox regression but the major difference is
based on the distribution that timing function is assumed to follow. Researchers
like (Wegbom, et al., 2016) examined the multivariate analysis of child
mortality in rural Nigeria, the study made use of Weibull distribution because it
has the ability to model Hazard functions that are monotonically decreasing or
increasing.
Therefore, this study intends to use standard Cox
proportional hazard models, Weibull distribution and Exponentiated-Weibull
distribution as the survival function to determine infant mortality in Nigeria.
1.3 AIMS AND OBJECTIVES OF STUDY
The aim of this study is to identify
the determinants of infant mortality in Nigeria using Cox proportional hazard model,
Weibull Cox proportional hazard model and Exponentiated Weibull proportional
hazard model. The specific objectives of the study are:
1.
To identify the determinants of infant
mortality in Nigeria
2.
To investigate the effect
of unobserved factors on infant mortality by fitting frailty model using the
best fitted model.
3.
To compare the results
obtained in (1) using the three statistical tools applied in the analysis.
1.4 SIGNIFICANCE OF STUDY
This study would be beneficial to the
government in the area of policy formulation that would help reduce the risk of
infant death in Nigeria. It is expected that when the rate of infant mortality is
reduced, it would be beneficial to parents because the rate of child loss will
be reduced significantly. This study
would be beneficial to other researchers as it will help contribute to the
existing literature on modeling the determinants of infant mortality in Nigeria.
1.5 SCOPE
OF STUDY
The scope of this study is limited to
identifying the determinants of infant mortality in Nigeria. The data used in
the study are derived from the 2013 Nigeria Demographics and Health Survey data
set.
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